I am using Vista Professional 32bit and my user is set as Administrator. I have a right clicked on notepad and selected run as administrator, then located the Hosts file and I have deleted the content that malware put there and but I can not save the file. I succesfully copied the file and modified it while in safe mode but it won't let me delete or paste over the original. The file is a Read-Only and it also won't let me change it to Non Read-Only. I have tired from reading posts that haven't solved the problem. I have run several different virus/spyware programs and all have said the pc is clean. I am just about ready to take a sludge hammer to the laptop. If anyone actually knows how to fix this please post. Thanks.