Just built a new computer: Intel i&-3770K; Asus Sabertooth Z77; 16G Dominator RAM; eVGA GTX 660 Ti; Corsair HX-750W PSU. Windows 8 Pro 64-bit is the OS and had been trouble-free on an earlier  X58-based system.

Right out of the gate, everything worked without problem. After a couple of days, however, the USB3 ports ceased functioning. Device Manager showed the following message for each of the two USB Root Hubs (xHCI) -- "Windows cannot start this hardware device because its configuration information (in the registry) is incomplete or damaged. (Code 19)". The computer uses two different Host Controllers: ASMedia USB 3.0 eXtensible Host Controller --0096 (Microsoft) and Intel USB 3.0 eXtensible Host Controller--0100 (Microsoft).

Asus RMAed the mainboard but the problem remained. All other hardware has tested clean. One suggestion they made was to roll back to Windows 7 -- supposedly Windows 8 doesn't play well with either of those Host Controllers. That's  a non-starter. The last suggestion made was that the back-plane was shorting out against the case. Of the many sugegstions I found for the problem, that's the silliest. BTW, I had planned to replace the case at one point anyway and went ahead this time -- the problem is still there. Even silly suggestions can be wrong.

I did a Refresh (twice) of Windows 8, retaining my data and apps. The problem went away -- for a couple of days. It's back.

All drivers are the latest and all Windows 8 updates have been installed.

Please help.

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Please try the Windows 7 USB 3.0 drivers from Intel:

https://downloadcenter.intel.com/Detail_Desc.aspx?DwnldID=21129

and look if this fixes it.