We are having issues with several clients where Thunderbird is hanging due to SCEP.  We are running the latest version of Thunderbird and the latest version of SCEP

SCEP: 4.7.214.0

Mozilla Thunderbird: 38.2.0

Has anyone else had this issue?  The only thing I can think of is simply to exclude the Thunderbird profile folder from SCEP, but I read that RTP doesn't use paths with wildcards in it.  I am not sure how it would be possible to exlude the thunderbird profile folder without using wildcards.

%systemdrive%\users\*\appdata\Roaming\Thunderbird

I would also prefer not to exclude the Thunderbird folder as this is a very important place to scan for viruses in incoming email.  Anyone else have this issue?

 I read that RTP doesn't use paths with wildcards in it. 

This has been a point of confusion for me as well. There are a few very old sources that mention this for FEP (like: http://blogs.technet.com/b/clientsecurity/archive/2010/03/08/wildcards-in-path-exclusions.aspx)

but I believe they are no longer valid for the current version of SCEP. Your example exclusion should be valid, according to this KB:

https://support.microsoft.com/en-us/kb/2962341

4.8.204.0 (KB304956) is actually the latest client version. I would update and see if you can still reproduce the problem