when I clicked on Help in the program and got the following.
Can you try just opening that file using normal file extension file type association? That's what I am doing with the SysInternals HLP files. Then as soon as the HelpPane.exe app opens, stop the trace. Also, it looks like you had File Access
events only filtered for your screen shot. The UI is not particularly clear because its tooltip is always the same regardless of the actual state of the button you are checking. However, it looks like one way of looking at it is that when it is
in a patch of blue the exclusion filter for that Event class is not present. E.g. compare the Filter list at the bottom with Event Class Profiling to see this. (Ctrl-L Backtab (from the OK button), End)
In any case, the idea would be to trace both yours and your wife's instances of that scenario. Then, in the Registry trace find out what the difference is that causes yours to diverge to HelpPane.exe
BTW I don't think you will actually have to filter just Registry events because usually they completely swamp any of the others. So, I would leave them all enabled for context.
FWIW while I am here I took a different tack on the trace. Finding the first instance of the CLSID which is involved {8CEC58E7-07A1-11D9-B15E-000D56BFE6EE}. These occur just a bit before the first HelpPane Find, so probably all 3 NOT FOUND events
if changed could significantly alter the flow
winhlp32.exe RegOpenKey NAME NOT FOUND HKLM\SOFTWARE\Microsoft\WindowsRuntime\CLSID\{8CEC58E7-07A1-11D9-B15E-000D56BFE6EE} Desired Access: Read
winhlp32.exe RegOpenKey NAME NOT FOUND HKCR\ActivatableClasses\CLSID\{8CEC58E7-07A1-11D9-B15E-000D56BFE6EE} Desired Access: Read
winhlp32.exe RegOpenKey NAME NOT FOUND HKCR\Wow6432Node\CLSID\{8CEC58E7-07A1-11D9-B15E-000D56BFE6EE}\TreatAs Desired Access: Query Value
The last one is the same as one I have already shown.
HTH