Config: Windows 7 Ultimate 64-bit ASRock MB - N68PV-GS AMD Phenom 8450 Toliman 2.1GHz 4Gb (2x2Gb) 240-pin DDR2 800 (PC2 6400) GeForce GTS 250 512MB 256-bit GDDR3 200Gb Seagate SATA C Drive 250Gb WD SATA D Drive After sitting for a varied amount of time, at least 12 hours, but sometimes more, system won't open any new applications or windows, such as: IE Outlook (OUTLOOK.EXE - Application Error.... The application was unable to start correctly (0xc0000142). Click OK to close the application. Control Panel - Window opens, but is blank white Sometimes, I'm able to restart, but often I can only "Shut Down" because the drop-down next to the Shut Down button won't drop-down.

Hi nsn1965, Please disable all startup items and third party services when booting. This method will help us determine if this issue is caused by a loading program or service. Please perform the following steps: 1. Click the Start Button type "msconfig" (without quotation marks) in the Start Search box, and then press Enter. Note: If prompted, please click Continue on the User Account Control (UAC) window. 2. Click the "Services" tab, check the "Hide All Microsoft Services" box and click "Disable All" (if it is not gray). 3. Click the "Startup" tab, click "Disable All" and click "OK". Then, restart the computer. When the "System Configuration Utility" window appears, please check the "Don't show this message or launch the System Configuration Utility when Windows starts" box and click OK. Please test this issue in the Clean Boot environment, if the issue disappears in the Clean Boot environment, you can continue to narrow down which entry is causing the issue. Also, scan your system with anti-virus and anti-spyware software to check the result.