After posting this thread, I was told to post here.
https://answers.microsoft.com/en-us/windows/forum/windows8_1-tms/lose-mouse-click-on-session-resume/e4ca4acf-4f96-4a1f-9e76-4c3665d1253e?auth=1
This gist of the problem is that when I resume a local session on my PC after I have had an RDP session open from home, occasionally, my mouse click function is gone. The cursor itself works, the keyboard works, but the click does not. Only a reboot fixes it.
I have replaced all my computer components, reloaded Windows 8.1 Enterprise, and replaced my keyboard and mouse. The problem persists.
One item of note, I have 3 monitors and after resuming a session my display might take 30-45 seconds to become functional due to all the windows I have open. I notice that this happens after some time has passed since my last reboot and usually when lots of windows are open.
Still, after all the hardware replacements, reloading of Windows, it seems to be a bug. Where do I go from here?