We've just setup a test WSE2102R2 box to test functionality with Windows 10 client (currently testing with Win 10 Enterprise).

We've got a number of clients running the server and when implementing we use the http://servername/connect to install the client connection software, then use the Client Configuration Wizard to migrate the current user profile across to the new domain account.

This doesn't work on Windows 10 clients.

The http://servername/connect doesn't work, so installed KB2790621 on the machine and ran through the wizards.  Asks the same questions as you'd get on Windows 7, but doesn't migrate the profile across, meaning it's either a manual 3 step process to get the data in there, or set everything up from scratch.

We've got customers running Windows 7 who are asking about Windows 10, and currently we are telling them October at the earliest.  Not sure why the OS doesn't work with one of the best small business products on the market.

According to this link WSE 2012R2 does not work with Windows 10 automatically, you have to install the connector manually