Hi John!
My follow-up question is does the proxy require authentication as noted in the Technet document
Step-by-Step Guide
to Deploying the Asset Inventory Service Client Software in the section
Configuring client computers that report to an authenticated proxy server.
From my understanding, WPAD [Web Proxy Auto discovery Protocol] is used to locate the Proxy Auto-Configuration [PAC] file and to configure
the proxy settings for the client. I don't suspect there would need to be any changes made, if you are using this as a method to configure the client to locate the proxy. However, if the "physical" proxy requires authentication, then you will need
to ensure that is done as noted in the Technet article. Does that help?
Here's a useful link related to WPAD -
http://www.findproxyforurl.com/ and
http://technet.microsoft.com/en-us/library/cc985335.aspx.
Hope this helps!
Angela