Is it possible to set all regional settings including date/time etc using a GPO? If so where could i find this setting to change all PCs to a default country/keyboard layout (mixture of Win XP, Vista, 7) Thanks

Check this article. For GPO help, post here. http://social.technet.microsoft.com/Forums/en-US/winserverGP/threads/ Thanks

I'd say yes for Windows Server 2008 R2. Regional Options Extension http://technet.microsoft.com/en-us/library/cc754496.aspx You need XP SP2 for the above to be implemented as per below article. Information about new Group Policy preferences in Windows Server 2008 http://support.microsoft.com/kb/943729