We have a Server 2008 standard edition,we have 3 partitions in my Hard disk, in one of the partition i cant able to set the permissions for administrator as well as domain users. 

Hi, I would like to know which account you used to log on, if you are local admin of the computer, then you should have right to do that. But I also would like to know that why you want to change administrator right on the drive, it is not recommended, as local administrator management is not like normal users. Regards, Yan LiYan Li TechNet Community Support

Hi, I would like to know which account you used to log on, if you are local admin of the computer, then you should have right to do that. But I also would like to know that why you want to change administrator right on the drive, it is not recommended, as local administrator management is not like normal users. Regards, Yan LiYan Li TechNet Community Support