This issue has been documented by several developers, but I haven't seen any responses from Microsoft. Wanted to bring it up again on this forum to see if anyone has gotten any further on this issue.
The issue is that RemoteApp client is sending WM_LBUTTONUP messages even when the user has not released the mouse button. Below are several other posts regarding the issue. In my testing, the problem only seems to occur when running Windows Remote Desktop Connections from Windows 7 and 8. Windows 10 client does not cause the issue. Oddly neither does the Microsoft's own Remote Desktop Client for the Mac!
https://social.technet.microsoft.com/Forums/windowsserver/en-US/6c2e1330-0150-4d28-b66b-f37fff58f00d/server-2008-r2-xp-sp37-64bit-client-remoteapp-dragging-window-problem?forum=winserverTS#7c5d2ba5-baa6-4ef0-91fd-4c3cad4acc65
https://social.technet.microsoft.com/Forums/windowsserver/en-US/e5db7477-b35e-4831-886d-9539da218fa5/wrong-wmlbuttonup-message-on-remoteapp?forum=winserverTS#eb72a692-cac7-4595-b1e2-f4be21dcd746