Every time I try to install SQL Server 2008 R2 Native Client and SQL Server 2008 System CLR Types I receive the following error: "An error occurred during the installation of assembly 'Microsoft.vc80.crt, version="8.0.50727.4027",publicKeyToken="1frc8b3b9a1e18e3b",processorArchitecture="amd64",type="win32". HRESULT:0x8007054F.

Hi Fanatic1217,

According to the error message, the issue could be caused by that the Microsoft.vc80.crt assembly is missing or corrupted.

As Microsoft.vc80.crt assembly belongs to Microsoft Visual C++ 2005 SP1 Redistributable Package, please download the correct version of Microsoft Visual C++ 2005 SP1 Redistributable Package from below links and install it on your server, then install SQL Server 2008 R2 Native Client again.

Microsoft Visual C++ 2005 SP1 Redistributable Package (x86)
Microsoft Visual C++ 2005 SP1 Redistributable Package (x64)

In addition, another cause could be due to .Net framework issue, you may need to uninstall .Net framework 4.0 and install .Net framework 3.5 sp1 , which is discussed in this similar thread.

Thanks,
Lydia Zhang