good attempt but not very clear what u try to say! it will be helpful if you discuss it with example and scenario. thanks
Look up page splits. A GUID is random and the typical PK is also the clustered index. Since a GUID is random (yes even the sequential ones are) and a clustered index is sorted then it is a very bad idea to do this.
A GUID is 16 bytes of data, INT is 4. EVERY COLUMN in the clustered index is in EVERY non-clustered index! This bloats the size of each index and the table.
I would say if you use a GUID for your PK make sure it IS NOT the clustered index key.