I've been on the phone with Microsoft 4 different callers and havent' gotten an answer.

This link http://www.microsoft.com/en-us/download/details.aspx?displaylang=en&id=16 shows at the top, you can't but at the bottom say's Supporting OS is 2008R2, so which is it? They tell me no it can't

What can I run on Windows Server 2008R2 to check for a Spam Bot, my postmaster@xxx.com is sending out Spam. I need to figure out if it's coming from the Server or if it is on a network machine.

You can install Windows Malicious Software removal tool on 2008 R2 and that works but only on that server i.e. underlying OS is protected not your mail server !. To protect your mail system, you need specific anti-spam security applications such as anti-spam products from Symantec or McAfee or MS forefront etc... for expert advise on anti-spam, please post it exchange Anti-virus/Anti-spam forum if you are using Exchange as Mail server http://social.technet.microsoft.com/Forums/en/exchangesvrantivirusandantispam/threads If you use third party mail servers, you might want to post this question in thier forums.Thanks !

This link http://www.microsoft.com/en-us/download/details.aspx?displaylang=en&id=16 shows at the top, you can't but at the bottom say's Supporting OS is 2008R2, so which is it? They tell me no it can't The above link is for 32Bit OS. For Windows 2008 R2 OS, you should download this. http://www.microsoft.com/en-us/download/details.aspx?id=9905 Note: This tool is not a replacement for an anti-virus product. To help protect your computer, you should use an anti-virus product. Thanks

I agree with MYousufAli, that doesn not replace a antivirus. But you can run tcpview too and check your connection status in your firewall. A infected computer will be using a lot of outcoming connection of port 25. A general tip if you have a Exchange or a mail server in your LAN block your firewall so only your server can go out on port 25. (If all your computer use your mail's server of course)MCP | MCTS 70-236: Exchange Server 2007, Configuring

Any updates ?Jeff Ren TechNet Community Support beneficial to other community members reading the thread.