how do it set up an out of office reply

Search engines still exist! :)

http://www.technipages.com/outlook-set-out-of-office-message

Hi Chrisics,

If you are an Exchange Admin,

Use the Set-MailboxAutoReplyConfiguration cmdlet to configure Automatic Replies settings for a specific mailbox.

https://technet.microsoft.com/en-us/library/dd638217%28v=exchg.150%29.aspx?f=255&MSPPError=-2147217396

If you had already tried searching for it, you should form a better question letting us know, what you have aleady tried. That would help us not guessing stuff.

Hi,

Automatic replies with an Exchange account

https://support.office.com/en-us/article/Automatic-replies-formerly-Out-of-office-assistant-2b77364d-21ed-4149-b913-4f150b738047?ui=en-US&rs=en-US&ad=US

Automatically reply to email messages without using an Exchange Server account

https://support.office.com/en-us/article/Automatically-reply-to-email-messages-without-using-an-Exchange-Server-account-a1f35f8b-d710-4bd6-b3ea-0d25c15bddf1?CTT=5&origin=HA102748964&CorrelationId=5d2dd674-42e3-4306-99ba-39a864fb7d21&ui=en-US&rs=en-US&ad=US

Best Regards.