Can anyone help me make sense of this error or point me in a direction?

Problem signature:
  Problem Event Name:                        APPCRASH
  Application Name:                             EXCEL.EXE
  Application Version:                           15.0.4719.1000
  Application Timestamp:                     552cf0b0
  Fault Module Name:                          StackHash_2ab1
  Fault Module Version:                        6.1.7601.18839
  Fault Module Timestamp:                  553e8808
  Exception Code:                                  c0000374
  Exception Offset:                                000cea5f
  OS Version:                                          6.1.7601.2.1.0.256.48
  Locale ID:                                             1033
  Additional Information 1:                  2ab1
  Additional Information 2:                  2ab19975b81668c12893e220c8fccca0
  Additional Information 3:                  ac7b
  Additional Information 4:                  ac7b7832568e6905ddb849a14bbfba16

Hi NMixer,

Based on the event log, it seems that StackHash Module caused this issue. The error usually occurs when DEP doesnt start, it is related to Data Execution Prevention.

Please try the following method, and check if it works.

1. Click on the Start menu and then go to the Control Panel
2. Click on System Maintenance and then System
3. Choose Advanced System Settings.
4. Under System Properties, select Settings from the Performance section at the top.
5. Click on the Data Execution Prevention tab.
6. Select Turn on DEP for all programs and services except those I select.
7. Select the excel.exe (C:\Program Files\Microsoft Office\Office15) and click Open to add it to your DEP Exceptions list.
8. Click OK to save your new settings.

Please refer to this similar case:

https://social.technet.microsoft.com/Forums/office/en-US/16aa503f-06ba-43d4-91be-d44017a13e1e/excel-crashes-on-save-of-new-spreadsheet?forum=excel

Please try this method and let me know if it works for you. If the issue still exists, please be a bit more precise explain your question so that I can get more accurate solutions to this problem. Im glad to help and follow up your reply.

Hope its helpful.

Regards,