Hi Chris,
Could you tell me the system requirements of your computer and the version of your Office?
Did your excel file contain any Macros or formulas?
Did this issue only appear in this 11MB particular file?
Where did you store the excel file, local computer or network?
I suggest you turn off automatic calculation function in Excel.
If your excel file stored in network, I suggest you try to disable Office File Validation, please go to:
HKEY_CURRENT_USER\Software\Microsoft\Office\1X.0\Excel\Options
Look for a DWORD value labeled DisableRobustifiedUNC set to a value of 1. If this is set on your machine, it's recommended you delete this value or set the DWORD value to 0.
Important Follow the steps in this section carefully. Serious problems might occur if you modify the registry incorrectly. Before you modify it, back up the registry for restoration in case problems occur.
Please refer to this article about how to back up and restore the registry in Windows:
https://support.microsoft.com/en-us/kb/322756?wa=wsignin1.0
Please try this method and check if it works for you.
Any updates please let me know, I'm glad to help and follow up your reply.
Regards,
Emi Zhang
TechNet Community Su