So, What I am trying to do is deploy Office 2013 throughout our company, and I do not want the users to save their business or personal files created within Office 2013 on the C: drive or Sky Drive. We have what is called the U: drive and I'd like to know if there's a quick registry tweak that I can use to not only change the default location upon setting up a computer, but to deploy through Group Policy? 

One other question perhaps; Is there a way to change not only the file location to default to only the one place, but also is there a way to also set a specific size limit to folders and prevent certain files from being saved (videos and personal pictures). 

I have our network pretty tight as to what or who can go where, and what not, I am just really for an answer or some help to the default location...anything you have GREATLY APPRECIATED! 

You can use the OCT and/or domain Group Policy, to customise the Office experience and settings for your users:
https://technet.microsoft.com/en-us/library/ee460874.aspx