Looks like a SCOM?MOM issue rather than Exchange. I would ask in the SCOM forums: http://social.technet.microsoft.com/Forums/en-US/category/systemcenteroperationsmanager

Running Exchange 2007 2 node cluster. Getting the error Learning Module Failed Execution, Alert Description Create Registry Key Software\Microsoft\Microsoft Operations Manager\3.0 Modules\Baselining\SignatureID Failed with error the handle is invalid. Instance Name is IIS Web Server. Has anyone come across this error and resolved.

Agree with Andy. Also suggest you seek the solution in the SCOM forum. Please remember to mark the replies as answers if they help and unmark them if they provide no help. If you have feedback for TechNet Subscriber Support, contact tnmff@microsoft.com.Frank Wang TechNet Community Support