We have just started to deploy Office 2013 64-bit onto Windows 7 64-bit.  I have had a number of users say that they are now getting a "General Mail failure, Quit Miccrosoft Excel, restart the mail system, and try again".  I have read all of the discussions about this from earlier versions and they all say that there is or has been an earlier version of Outlook running or installed on the computer.  I have a computers with a fresh install of Windows 7 64-bit, and a fresh install of Office 2013 64-bit (no previous versions ever installed on computer) and my user is getting this error.

I have tried all of the suggestions in for the previous versions of Office to fix this issue with no success.  I would appreciate any suggestions or help.

    Hello,

Does any of the following help:
1) Check the properties for your outlook shortcut. Under the compatability tab uncheck "run as administrator"
2) Rename Mapi32.dll (found in C:\Windows\system32) to Mapi32.old and then run FIXMAPI.exe
3) Export HKEY_LOCAL_MACHINE\SOFTWARE\Clients\Mail\Microsoft Outlook
reg key , Open this is in notepad and past the contents here.
4) Do we have Exchange installed on these clients ?
5) Do you have the following registry hive present ?
HKLM\Software\Microsoft\windows messaging subsystem\MSMapiApps
If this is present please Export and rename the "MSMapiApps" hive. Please exit Outlook client before renaming the hive.
6) Do you have the following registry hives present ?
a) HKEY_CURRENT_USER\Software\Microsoft\Office\
b) HKEY_CURRENT_USER\Software\Microsoft\Exchange
c) HKEY_LOCAL_MACHINE\Software\Microsoft\Exchange\Client\Extensions
d) HKEY_LOCAL_MACHINE\Software\Microsoft\Office
If this is present please Export and rename the hives.Please exit Outlook client before renaming the hives.

Please collect info or try the steps listed above and let us know if it works ?