Sorry let me clarify some of the config a little more.
MAIL101 - Exch 2013
MAIL102 - Exch 2013
AP104 - Witness (strictly a witness nothing else on this machine)
EDGE01 - Exch 2007 Edge
CAS01 - Exch 2007 Hub/CAS load balancer for CAS02/03
CAS02 - Exch 2007 Hub/CAS
CAS03 - Exch 2007 Hub/CAS
MBOX01 - Exch 2007 Mail cluster
MBOX02 - Exch 2007 Mail cluster node
MBOX03 - Exch 2007 Mail cluster node
RDC01, RDC02, RDC03 - all 2008 R2 root domain controllers for rootdomain.rootdomain
DC01, DC02, DC03, DC04 - all 2008 R2 domain controllers for us.rootdomain.rootdomain
All DCs are Global Catalogs.
I can ping all DCs and root DCs fromboth MAIL101 and 102
The Exchange Replication service is running on both MAIL101 and 102.
DC03 is in the same site as the MAIL101/102 servers so I'll run all replication tests from here.
DCDIAG comes back with all tests passed.
repadmin /replsum comes back with 0 fails and no errors largest delta for any intersite communication is 13min.
When I run Test-ReplicationHealth -Identity MAIL101 and also 102 they both come back as everything passed. No errors.