I get this error when opening the Management Console on Exchange 2010. The Exchange Trusted Subsystem is a local Admin.MCITP Exchange 2010 | MCTS Exchange 2007 | MCITP Lync Server 2010 | MCTS Windows 2008 | MCSE 2003

Have you tried solution from here? 2147024891 Access is denied: error in EMC http://exchangeshare.wordpress.com/2008/07/05/2147024891-access-is-denied-error-in-emc/James Chong MCITP | EA | EMA; MCSE | M+, S+ Security+, Project+, ITIL msexchangetips.blogspot.com

It is already set to Impersonate.MCITP Exchange 2010 | MCTS Exchange 2007 | MCITP Lync Server 2010 | MCTS Windows 2008 | MCSE 2003

What if you right click the emc and do right as administrator does it work?James Chong MCITP | EA | EMA; MCSE | M+, S+ Security+, Project+, ITIL msexchangetips.blogspot.com

I always open the EMC by right-clicking. To make matters more complicated and maybe this explains the behavior, this client has a very unusal setup here. They have 1 Forest with two domains. However, the domains are different trees. Each domain has one Exchange 2010 server. Not sure if there is some permissions issue here, but the error is Access is Denied.MCITP Exchange 2010 | MCTS Exchange 2007 | MCITP Lync Server 2010 | MCTS Windows 2008 | MCSE 2003