Hi Tony,
Thank you for your question.
Issue1:
A: we could do that which have no active user base in the off-site datacenter.
Issue2:
A: we could refer to the following links:
http://blogs.technet.com/b/rmilne/archive/2014/07/21/vmware-issues-with-exchange-dag.aspx
https://technet.microsoft.com/en-us/library/dd298065(v=exchg.150).aspx
Notice: although some links is about Exchange 2010, but it was adapted to Exchange 2013.
Issue3:
A: we think HA/DR in a single site is a better solution.
If there are any questions regarding this issue, please be free to let me know.
Best Regard,
Jim