Hi, I noticed the setup files are in the AMD64 folder, please ensure the architecture of the server is also AMD64. If not, please run the setup.exe in the i386 folder. If the issue persists, please also try the installation with the command prompt and see if it works: How to Use a Command Prompt to Install System Center Essentials 2010 http://technet.microsoft.com/en-us/library/ff603580.aspx Hope this helps. Thanks. Nicholas Li - MSFT Please remember to click Mark as Answer on the post that helps you, and to click Unmark as Answer if a marked post does not actually answer your question. This can be beneficial to other community members reading the thread.