am getting Time out issue some particular time only is there any database or connection issue Please find the below error and advice

Error Description :         Connection Timeout Expired.  The timeout period elapsed while attempting to consume the pre-login handshake acknowledgement.  This could be because the pre-login handshake failed or the server was unable to respond back in time.  The duration spent while attempting to connect to this server was - [Pre-Login] initialization=7; handshake=14

There can be many reasons. So you are getting timeout issue when connecting Via SSMS, Application, some other tool how ?

@Shanky_621

Via Application

@Shanky_621

Via Applic

make sure the credentials used in your connection string are working.

your application is causing this error may be you have ling running queries in the background. 

you need to find out what queries are running in your page that causing the time out.

yes am getting particular database it is cache-database

Any specific error message in errorlog :NO IN SQL ERRORLOG