Hi,

I am getting mysites error intermittently: 

Sorry, something went wrong 
Could not load user profile. 
Technical Details 


Troubleshoot issues with Microsoft SharePoint Foundation. 
Correlation ID: cdfb279d-69f1-60c5-dba2-32e9da0d72f1 
Date and Time: 8/27/2015 6:09:59 AM 

Exception occurred loading user profile (/default.aspx): Microsoft.Office.Server.UserProfiles.UserProfileApplicationNotAvailableException: UserProfileApplicationNotAvailableException_Logging :: UserProfileApplicationProxy.ApplicationProperties ProfilePropertyCache does not have 80e5e544-748e-4b4e-b16b-07c0e84ed00b    
 at Microsoft.Office.Server.Administration.UserProfileApplicationProxy.get_ApplicationProperties()    
 at Microsoft.Office.Server.Administration.UserProfileApplicationProxy.get_ProfileDBSqlSession()    
 at Microsoft.Office.Server.UserProfiles.UserProfile.RetrieveUser(String strAcct, Guid gAcct, Byte[] bSid, Nullable`1 recordId, Boolean doNotResolveToMasterAccount, Boolean loadFullProfile, Boolean loadColleagueRecordIds, String strEmail)    
 at Microsoft.Office.Server.UserProfiles.UserProfile..ctor(UserProfileManager objManager, String strAcct, Boolean doNotResolveToMasterAccount, Boolean forceUserIsSelf, Boolean loadFullProfile, Boolean loadColleagueRecordIds, String strEmail)    
 at Microsoft.Office.Server.UserProfiles.UserProfileManager.GetUserProfile(Boolean bCreateIfNotExist, Boolean loadFullProfile, Boolean loadColleagueRecordIds)    
 at Microsoft.Office.Server.UserProfiles.ProfileLoader.EnsureUserProfile(Boolean bCreateIfNotExist)    
 at Microsoft.Office.Server.UserProfiles.ProfileLoader.GetUserProfile(Boolean bCreateIfNotExist)    
 at Microsoft.SharePoint.Portal.WebControls.ProfilePropertyLoader.OnInit(EventArgs e).

I always end up restarting User Profile Synchronization Service in App Server. Im searching for root cause and permanent fix.

Your response is appreciated.

Thanks,

-Fran