I have 16 DP's in Config manager all were working last week. Now only 2 are allowing content. The error message states:

Possible cause: Distribution Manager does not have sufficient rights to the computer.

Solution: Verify that the site server computer account is an admin on the distribution point computer.

I have done all this. As I stated they were all working last week No permission changes have been made. I am stumped.

What does the distmgr.log show?

Any other changes to the environment since last week?

Jeff

2015-04-27 09:16:03, Info                  DISM   API: PID=1468 TID=27340 Lookup in table by path failed for: DummyPath-2BA51B78-C7F7-4910-B99D-BB7345357CDC - CTransactionalImageTable::LookupImagePath

Hi,

Any error about the access to the DP share in distmgr.log? You could also check the IIS log on the DP.

Best Regards,

Joyce

Something could have happened to your boundary groups assigned to your DP and DP groups. Make sure all is configured the way it should be.

Please add details about the issue. Are you talking about distributing content to DPs? Or that clients cannot download content? 
Also the log above does not look like it's distmgr.log. "DISM" in distmgr.log does not look familiar to me. Please add some more lines.