I've got the same problem, as well as what appears to be countless others who have upgraded to Windows 10 and now experiencing that multiple monitors/display don't work anymore. Common trait seems to be when computer has more than one video adapter. Common trait seems to be when computer has more than one video adapter, nVidia and/or AMD and/or Intel. In my case, all adapters are supported by Windows 10 running latest drivers as of this post. If I can disable either video adapter, the other adapter will works with the respective attached monitors. GPU acceleration is working, and Windows detects all displays in device manager. It appears to be a Windows problem as according to nVidia, Windows now has full control over manipulating multi display layouts. Thoughts?

Thanks

MWfor64bit

First, I would like to know how you connect multiple monitor on your computer.

If you use multi-monitor adapter which can work in Windows old operation, but not Windows 10, I recommend you install the latest driver in compatibility mode to check the results:

To install in compatibility mode do the following:

Right click the installer>Choose Properties>Under Compatibility tab>Choose OS

http://windows.microsoft.com/en-US/windows-vista/Make-older-programs-run-in-this-version-of-Windows?SignedIn=1