I have had a few Management point failures where it stops recently about 2 over 2 months so nothing too drastic just a bit annoying, in it the management point stops responding it has done it once on my central and then again on one of my primaries. In the circumstance it just stops responding to HTTP calls, it always seems to be towards the end of the week and a reboot fixes it. Has anyone else come across this and is there anything anyone is aware of that can cause this ? Its not at backup times its always during the day.

Hope following article can help you. ConfigMgr 2007: MPControl.log shows HttpSendRequestSync fails with status code 500 'Internal Server Error' http://blogs.technet.com/b/smsandmom/archive/2008/09/04/configmgr-2007-mpcontrol-log-shows-httpsendrequestsync-fails-with-status-code-500-internal-server-error.aspx

You can try below- http://microsoftteched.com/2009/11/25/troubleshoot-the-issue-of-error-500-when-accessing-smssccm-reports/ Thx.