Hi, We have a scenario, where multiple moss 2007 farms need to be published over the extranet using ISA 2006 link translation.We are using https to http bridging. The problem we are facing while publishing the sharepoint farm is with _layouts folder of sharepoint. ISA could differentiate _layouts for correspondence server for individual website published in extranet. could anybody help to solve this issue.

Could you please let me know why do you need ISA Link Translation? Have you configured AAM in SharePoint?Have you read this http://blogs.msdn.com/sharepoint/archive/2007/03/06/what-every-sharepoint-administrator-needs-to-know-about-alternate-access-mappings-part-1.aspx?