Recently I noticed all of my applications start to fail at distributing across my infrastructure to various servers. As time goes on more and more fail to distribute to various servers. If I export/import the application or remove distribution points from it and redistribute it usually fully distributes.

I get the following errors in distmgr.log. I am unable to find any relevant errors in other logs. 

Package ZP100061 does not have a preferred sender.  SMS_DISTRIBUTION_MANAGER    9/11/2015 8:37:26 AM    10884 (0x2A84)
STATMSG: ID=2333 SEV=I LEV=M SOURCE="SMS Server" COMP="SMS_DISTRIBUTION_MANAGER" SYS=<Primary Server> SITE=ZP1 PID=3208 TID=10884 GMTDATE=Fri Sep 11 13:37:26.617 2015 ISTR0="ZP100061" ISTR1="<Site Server>" ISTR2="" ISTR3="" ISTR4="" ISTR5="" ISTR6="" ISTR7="" ISTR8="" ISTR9="" NUMATTRS=1 AID0=400 AVAL0="ZP100061"  SMS_DISTRIBUTION_MANAGER    9/11/2015 8:37:26 AM    10884 (0x2A84)
Needs to send the compressed package for package ZP100061 to site <Site Server> SMS_DISTRIBUTION_MANAGER    9/11/2015 8:37:26 AM    10884 (0x2A84)
Sending a copy of package ZP100061 to site <Site Server>    SMS_DISTRIBUTION_MANAGER    9/11/2015 8:37:26 AM    10884 (0x2A84)
The reporting site of site <Site Server> is this site.  SMS_DISTRIBUTION_MANAGER    9/11/2015 8:37:26 AM    10884 (0x2A84)
Use drive C for storing the compressed package. SMS_DISTRIBUTION_MANAGER    9/11/2015 8:37:26 AM    10884 (0x2A84)
CContentBundle::AddContentDefinitionItems failed; 0x80070003    SMS_DISTRIBUTION_MANAGER    9/11/2015 8:37:26 AM    10884 (0x2A84)
CDistributionManager::AddContentToBundle failed; 0x80070003 SMS_DISTRIBUTION_MANAGER    9/11/2015 8:37:26 AM    10884 (0x2A84)
CDistributionManager::CreatePackageBundle failed; 0x80070003    SMS_DISTRIBUTION_MANAGER    9/11/2015 8:37:26 AM    10884 (0x2A84)
Error creating package bundle to send copy of package ZP100061 to site <Site Server>.   SMS_DISTRIBUTION_MANAGER    9/11/2015 8:37:26 AM    10884 (0x2A84)
The package and/or program properties for package ZP100061 have not changed,  need to determine which site(s) need updated package info.    SMS_DISTRIBUTION_MANAGER    9/11/2015 8:37:26 AM    10884 (0x2A84)
CDistributionSrcSQL::UpdateAvailableVersion PackageID=ZP100061, Version=1, Status=2302  SMS_DISTRIBUTION_MANAGER    9/11/2015 8:37:26 AM    10884 (0x2A84)
StoredPkgVersion (1) of package ZP100061. StoredPkgVersion in database is 1.    SMS_DISTRIBUTION_MANAGER    9/11/2015 8:37:26 AM    10884 (0x2A84)
SourceVersion (1) of package ZP100061. SourceVersion in database is 1.  SMS_DISTRIBUTION_MANAGER    9/11/2015 8:37:26 AM    10884 (0x2A84)
STATMSG: ID=2302 SEV=E LEV=M SOURCE="SMS Server" COMP="SMS_DISTRIBUTION_MANAGER" SYS=<Primary Server> SITE=ZP1 PID=3208 TID=10884 GMTDATE=Fri Sep 11 13:37:26.804 2015 ISTR0="TeamViewerQS ver. 9" ISTR1="ZP100061" ISTR2="" ISTR3="" ISTR4="" ISTR5="" ISTR6="" ISTR7="" ISTR8="" ISTR9="" NUMATTRS=1 AID0=400 AVAL0="ZP100061"    SMS_DISTRIBUTION_MANAGER    9/11/2015 8:37:26 AM    10884 (0x2A84)
Failed to process package ZP100061 after 42 retries, will retry 58 more times   SMS_DISTRIBUTION_MANAGER    9/11/2015 8:37:26 AM    10884 (0x2A84)
Exiting package processing thread for package ZP100061. SMS_DISTRIBUTION_MANAGER    9/11/2015 8:37:26 AM    10884 (0x2A84)

• Edited by SCCMheadache 16 hours 18 minutes ago

0x80070003 = The system cannot find the path specified.

You sure file are accessible. Maybe try to access them path using the system account.

Sometime the path is to long 254 char.

They are accessible. The system account also has access. This has been verified. When I exported and then imported an application I set the content location back to the original location and it deploys fine.